Provided they are well cared for, rabbits make friendly and playful pets. They are widely kept throughout the world, both indoors and out.

Rabbits kept indoors are typically healthier and more social than rabbits kept outdoors. Housed indoors and provided with adequate damage-proofing (especially of electrical cables), rabbits are relatively safe from predators, disease, and temperature extremes. Rabbits kept outdoors must be provided with shelter that is heated in winter and shaded in summer.

Domesticated rabbits are most comfortable in temperatures between 10 to 21 degrees Celsius (50 to 70 degrees Fahrenheit), and cannot endure temperatures above 32 degrees Celsius (90 degrees Fahrenheit). Veterinarians specializing in rabbits recommend a diet consisting of hay, water, and small amounts of pellets. Other organic vegetables, such as carrots, are recomneded as dietary supplements, but light greens, such as iceberg lettuce, can cause carbon dioxiode gas bubbles in their dietary tracts that can lead to their early death.

Rabbits are crepuscular, meaning they are most active at dawn and dusk; rabbit owners find that these times correspond nicely with their working days. Rabbits sleep intermittently, taking on average 18 naps a day. As prey animals, rabbits behave differently from predator companion animals such as cats and dogs. For example, they have lower 'running expenses', and do not tolerate games of chase.

 Although well known for hopping, rabbits' spines are inflexible and delicate and they dislike being handled. For these reasons, they are better suited for older teens and adults than for children.